It's not known how much promethazine passes into breast milk but it is likely to be a small amount. It has been used for many years without causing babies to have side effects. However, promethazine is a drowsy antihistamine, so may also make your baby sleepy too. It may also reduce the amount of milk you produce.
Promethazine is well absorbed from the gastrointestinal tract. Clinical effects are apparent within 20 minutes after oral administration and generally last four to six hours, although they may persist as long as 12 hours. Promethazine is metabolized by the liver to a variety of compounds; the sulfoxides of promethazine and N-demethylpromethazine are the predominant metabolites appearing in the urine.
The combination of promethazine hydrochloride, phenylephrine hydrochloride and codeine phosphate is contraindicated in pediatric patients less than 6 years of age, because the combination may cause fatal respiratory depression in this age population.
The combination of promethazine hydrochloride, phenylephrine hydrochloride and codeine phosphate is contraindicated in pediatric patients less than 6 years of age. Concomitant administration of promethazine products with other respiratory depressants has an association with respiratory depression, and sometimes death, in pediatric patients.
Postmarketing cases of respiratory depression, including fatalities, have been reported with use of promethazine hydrochloride in pediatric patients less than 2 years of age. A wide range of weight-based doses of promethazine hydrochloride have resulted in respiratory depression in these patients.
Respiratory depression leading to arrest, coma and death has occurred with the use of codeine antitussives in young children, particularly in the under-one-year infants whose ability to deactivate the drug is not fully developed.
Excessively large dosages of antihistamines, including promethazine hydrochloride, in pediatric patients may cause sudden death (see OVERDOSAGE). Hallucinations and convulsions have occurred with therapeutic doses and overdoses of promethazine hydrochloride in pediatric patients. In pediatric patients who are acutely ill associated with dehydration, there is an increased susceptibility to dystonias with the use of promethazine HCl.
Promethazine, phenylephrine and codeine may cause marked drowsiness or may impair the mental and/or physical abilities required for the performance of potentially hazardous tasks, such as driving a vehicle or operating machinery. Ambulatory patients should be told to avoid engaging in such activities until it is known that they do not become drowsy or dizzy from promethazine, phenylephrine and codeine therapy. The concomitant use of alcohol or other central nervous system depressants, including narcotic analgesics, sedatives, hypnotics and tranquilizers, may have an additive effect and should be avoided or their dosage reduced.
Sedating drugs may cause confusion and over-sedation in the elderly; elderly patients generally should be started on low doses of promethazine hydrochloride, phenylephrine hydrochloride and codeine phosphate syrup and observed closely.
It is important that promethazine hydrochloride, phenylephrine hydrochloride and codeine phosphate syrup is measured with an accurate measuring device (see PRECAUTIONS-Information For Patients). A household teaspoon is not an accurate measuring device and could lead to overdosage, especially when half a teaspoon is to be measured. It is strongly recommended that an accurate measuring device be used. A pharmacist can provide an appropriate device and can provide instructions for measuring the correct dose.
Reviewed by: Kid B. Karen Coats Dalecki, Linden Kid B. Graphia/Houghton, 2006246p Paper ed. ISBN 0-618-60566-5$7.99 R Gr. 7-10 Breslin's life is both depressed and depressing: his real mom committed suicide, his dad is always on the road, and his stepmom and his older brother are hooking up. He's a failure at school, and he's looking at a life of back-breaking work at one of the oil refineries in his hometown of Beaumont, Texas, if they'll take him without a diploma. In the cypher, though, that magical circle where break dancers defy gravity, Breslin is Kid B, a white b-boy with mad skillz. He and his Krew are looking to represent at a Throw Down in Houston, but they'll settle for beating their chief rivals, Magno Clique. The narrative arc seems on the one hand to be a Cinderella story for Kid B, but the complications of his realization of the first step of his dream (a contract to dance back-up for a famous singer, awarded as much for his race as for his talent), and the unfinished business that he leaves behind with his Krew make his escape from Beaumont more poignant than jubilant. He knows that competitive team break dancing is a substitution for real gang violence, and that it sometimes fails; he also knows that it's a physically demanding sport hampered by the misunderstanding of those outside the culture. What makes this novel distinctive, though, is the authenticity of Kid's voice. Some of the expressions [End Page 248] and language are local to the east Texas hip-hop community (such as \"liquid bar,\" which refers to a purple mixture of promethazine with codeine cough syrup and Sprite, known elsewhere as simply \"syrup\"), but most of the vocabulary is popular urban slang, and Kid B does a good job of describing the various break dance moves that he names, such as windmills, bellymills, suicides, etc. Kid's narration is fully stylized insider hip-hop fo' shizzle, making this an informative ethnography of b-boy culture for outsiders, and a great way to entice readers who are more at home on cardboard than carpet. 781b155fdc